【摘要】 目的 探讨近视人群脉络膜厚度（CT）与屈光度数及眼压的关系。方法 横断面研究。使用频域OCT测量118例近视患者黄斑中心凹及距中心凹0.5、1.0、2.5 mm的颞侧、鼻侧、上方、下方CT，采用非接触眼压计测量眼压，记录等效球镜度，取右眼数据进行单因素方差分析、相关性分析、多元线性回归分析。结果 距离中心凹1.0、2.5 mm的鼻侧脉络膜显著薄于黄斑中心凹及其余3个方位（P<0.01）。黄斑中心凹、距离中心凹0.5 mm和1.0 mm的4个方位CT与等效球镜度均呈负相关（r=-0.330、-0.207、-0.205、-0.272、-0.317、-0.283、-0.269、-0.212、-0.252，P<0.05）；距离黄斑中心凹2.5 mm的4个方位CT与等效球镜度不相关。距离黄斑中心凹2.5 mm的鼻侧CT与眼压不相关，其余各位点的CT均与眼压呈负相关（r=-0.295、-0.358、-0.459、-0.675、-0.315、-0.285、-0.314、-0.322、-0.295、-0.392、-0.336、-0.317，P<0.01）。通过多元线性回归，建立如下方程：黄斑中心凹下CT（μm）=345.22-4.54×眼压（mmHg）-7.57×等效球镜度数（D）（F=12.51，P<0.01）。结论 黄斑中心凹及靠近中心凹的各位点的CT随着屈光度数增加而变薄，远离中心凹的CT未受影响。大部分位点的CT随着眼压降低而增厚。
【关键词】 近视； 脉络膜厚度； 眼压； 屈光不正
DOI：10.3760/cma.j.issn.1674-845X.2014.06.007
基金项目：国家自然科学基金（81200713）；上海市第一人民医院优秀医学青年人才培养计划项目（12RC06）；上海交通大学“医工（理）交叉研究基金”（YG2011MS62）；上海市自然科学基金（09ZR1425400）
作者单位：200080 上海交通大学附属第一人民医院眼科
通信作者：柯碧莲，Email：kebilian@126.com
The relationship between choroidal thickness and equivalent power and intraocular pressure in a myopic population Li Min， Cheng Huiqin， Yuan Ying， Wang Jia， Ke Bilian. Department of Ophthalmology， First People′s Hospital of Shanghai Affiliated to Shanghai JiaoTong University， Shanghai 200080， China
Corresponding author：Ke Bilian，Email：kebilian@126.com
【Abstract】 Objective To investigate the relationship between choroidal thickness （CT） and equivalent power and intraocular pressure （IOP） in a myopic Chinese population. Methods This cross-sectional study included 118 myopic patients. Choroidal thickness was measured at the fovea and 0.5， 1.0 and 2.5 mm temporal， nasal， superior， and inferior to the fovea using spectral-domain OCT. IOP was measured with a non-contact tonometer. Refractive error was described as equivalent power. The data of the right eyes were analyzed with a one-way ANOVA， correlation analysis， and linear regression analysis. Results CT at 1.0 and 2.5 mm nasal to the fovea was thinner than CT at the fovea and the three other directions （P<0.01）. CT at the fovea and 0.5 and 1.0 mm temporal， nasal， superior， and inferior to the fovea were negatively correlated with equivalent power （r=-0.330， -0.207， -0.205， -0.272， -0.317， -0.283， -0.269， -0.212， -0.252； P<0.05）. No correlation was found between equivalent power and CT at 2.5 mm temporal， nasal， superior， and inferior to the fovea. There was no correlation between CT at 2.5 mm nasal to the fovea and IOP. CT at other locations was negatively correlated with IOP （r=-0.295， -0.358， -0.459， -0.675， -0.315， -0.285， -0.314， -0.322， -0.295， -0.392， -0.336， -0.317； P<0.01）. The formula obtained with multiple linear regression analysis was as follows： CT at the fovea （μm）=345.22-4.54×IOP （mmHg）-7.57× equivalent power （D） （F=12.51， P<0.01）. Conclusion CT at the fovea and close to the fovea became thinner as equivalent power increased， but CT away from the fovea was not affected by equivalent power. CT at most locations became thicker as IOP decreased.
【Key words】 Myopia； Choroidal thickness； Intraocular pressure； Refractive error